Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years
نویسندگان
چکیده
منابع مشابه
Cerebrospinal fluid and -amyloid(1-42) in dementia disorders
The reliability of cerebrospinal fluid (CSF)and CSF-amyloid assays for diagnosis of Alzheimer’s disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt–Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSFlevels can di...
متن کاملStudy of Cerebrospinal Fluid Tissue Transglutaminase , T - TAU , Amyloid Β 42 in Alzheimer ’ s Disease
Biochemical markers for Alzheimer disease would be of great value, especially to help in early diagnosis of the disease. The current study has focused on three candidates that have been suggested to be indulged in the pathogenesis of Alzheimer’ disease (AD): Tissue transglutaminase (tTG) activity, β-amyloid42 (Aβ 42) and total T-tau (T-tau). The study included 15 patients with probable AD, 15 p...
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IMPORTANCE Alzheimer disease has a long preclinical stage characterized by β-amyloid (Aβ) accumulation without symptoms. Several trials focus on this stage and use biomarkers to include Aβ-positive participants, but an even earlier prevention of Aβ accumulation may be an effective treatment strategy. OBJECTIVE To determine whether people who appear to be Aβ negative but are at high risk for A...
متن کاملIs standardization more important than methodology for assay of total protein in cerebrospinal fluid?
Four manual micromethods for protein determination, two turbidimetric (trichloroacetic and sulfosalicylic acid-sodium sulfate) and two colorimetric (Lowry and Coomassie Brilliant Blue--sodium dodecyl sulfate, CBB-SDS) were used to compare the standard curves for total protein (0.30 to 3 g/L) produced with three reference materials: bovine serum albumin, human serum albumin, and diluted human se...
متن کاملA Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid
Amyloid beta (aβ) protein assembles into larger protein aggregates during the pathogenesis of Alzheimer's disease (AD) and there is increasing evidence that soluble aβ oligomers are a critical pathologic species. Diagnostic evaluations rely on the measurement of increased tau and decreased aβ42 in the cerebrospinal fluid (CSF) from AD patients and evidence for oligomeric aβ in patient CSF is co...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2017
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2017.06.2264